Our undercover investigator was employed at Inotiv, an animal testing laboratory in Indiana, from August 2021 to March 2022. While there, she developed a unique relationship with two very playful primates, Ziggy and Chloe. See their endearing and heartbreaking story. And help us put an end to cruel animal testing methods.
You can help animals like Ziggy and Chloe—please take a moment to contact the FDA and urge them to stop relying on outdated animal testing and instead commit to and prioritize a shift towards more accurate non-animal test methods.
We revealed the results of an approximately seven-month undercover investigation at Inotiv, an animal testing laboratory in Indiana where thousands of animals, including dogs, primates, pigs, mice and rats are killed every year. The investigation reveals the suffering and death of these animals for toxicity testing of drugs.
From August 2021 to March 2022, an undercover investigator was employed at the facility and assigned to work on more than 70 toxicity studies commissioned by over two dozen pharmaceutical companies involving more than 6,000 animals.
The animals spent their days behind bars and were subjected to painful procedures such as force-feeding substances via stomach tubes, injections and multiple blood draws. Young primates were often held in restraint chairs for long periods of time during these procedures. Most of the animals were killed at the end of the studies, as is typical for any drug testing.
Close to 90% of drugs tested on animals ultimately fail in human trials, with approximately half of those failures due to unanticipated human toxicity, despite no toxicity having been observed in animals. An example unfolded during the investigation when Aligos Therapeutics ended pursuit of a drug being tested on mice and primates at Inotiv while the HSUS investigator was there. The biopharmaceutical company halted the tests because of unexpected toxicity in a human clinical trial. One person was hospitalized, and three others suffered from adverse effects.
There is evidence that non-animal approaches, such as organ-chip technologies, artificial intelligence, 3D printing and various other approaches, alone or in combination, provide superior results that will ultimately improve drug success rates for humans while sparing animals. The largest organ-chip study conducted to date demonstrated that liver chips detected toxicity in almost seven out of every eight drugs that proved toxic in human patients even after animal tests did not reveal that the drugs were toxic in the animal models.
|cookielawinfo-checkbox-advertisement||1 year||The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Advertisement".|
|cookielawinfo-checkbox-analytics||1 year||This cookies is set by GDPR Cookie Consent WordPress Plugin. The cookie is used to remember the user consent for the cookies under the category "Analytics".|
|cookielawinfo-checkbox-necessary||1 year||This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".|
|cookielawinfo-checkbox-others||1 year||This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Others".|
|cookielawinfo-checkbox-performance||1 year||This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".|
|CookieLawInfoConsent||1 year||Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.|
|lang||This cookie is used to store the language preferences of a user to serve up content in that stored language the next time user visit the website.|
|player||1 year||This cookie is used by Vimeo. This cookie is used to save the user's preferences when playing embedded videos from Vimeo.|
|sp_landing||1 day||The sp_landing is set by Spotify to implement audio content from Spotify on the website and also registers information on user interaction related to the audio content.|
|sp_t||1 year||The sp_t cookie is set by Spotify to implement audio content from Spotify on the website and also registers information on user interaction related to the audio content.|
|_ga||2 years||This cookie is installed by Google Analytics. The cookie is used to calculate visitor, session, campaign data and keep track of site usage for the site's analytics report. The cookies store information anonymously and assign a randomly generated number to identify unique visitors.|
|_gat_gtag_UA_5233154_5||1 minute||This cookie is set by Google and is used to distinguish users.|
|_gid||1 day||This cookie is installed by Google Analytics. The cookie is used to store information of how visitors use a website and helps in creating an analytics report of how the website is doing. The data collected including the number visitors, the source where they have come from, and the pages visted in an anonymous form.|
|CONSENT||16 years 5 months 2 days 6 hours||These cookies are set via embedded youtube-videos. They register anonymous statistical data on for example how many times the video is displayed and what settings are used for playback.No sensitive data is collected unless you log in to your google account, in that case your choices are linked with your account, for example if you click “like” on a video.|
|vuid||2 years||This domain of this cookie is owned by Vimeo. This cookie is used by vimeo to collect tracking information. It sets a unique ID to embed videos to the website.|
|fr||3 months||The cookie is set by Facebook to show relevant advertisments to the users and measure and improve the advertisements. The cookie also tracks the behavior of the user across the web on sites that have Facebook pixel or Facebook social plugin.|
|IDE||1 year 24 days||Used by Google DoubleClick and stores information about how the user uses the website and any other advertisement before visiting the website. This is used to present users with ads that are relevant to them according to the user profile.|
|NID||6 months||This cookie is used to a profile based on user's interest and display personalized ads to the users.|
|test_cookie||15 minutes||This cookie is set by doubleclick.net. The purpose of the cookie is to determine if the user's browser supports cookies.|
|VISITOR_INFO1_LIVE||5 months 27 days||This cookie is set by Youtube. Used to track the information of the embedded YouTube videos on a website.|
|YSC||session||This cookies is set by Youtube and is used to track the views of embedded videos.|
|yt-remote-connected-devices||never||YouTube sets this cookie to store the video preferences of the user using embedded YouTube video.|
|yt-remote-device-id||never||YouTube sets this cookie to store the video preferences of the user using embedded YouTube video.|
|yt.innertube::nextId||never||These cookies are set via embedded youtube-videos.|
|yt.innertube::requests||never||These cookies are set via embedded youtube-videos.|
|__jid||30 minutes||No description available.|
|cookielawinfo-checkbox-functional||1 year||The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".|
|disqus_unique||1 year||No description available.|
|loglevel||never||No description available.|
|wp-disclamer-popup||3 months||No description|
In relazione alla tematica trattata dal sito, alcuni contenuti presenti potrebbero contenere immagini forti o scene cruente che potrebbero turbare la sensibilità in soggetti emotivi. Per maggiori informazioni leggi il Disclaimer completo.
Informiamo inoltre che il sistema di valutazione dei contenuti del sito (Mi piace / Non mi piace) è da intendersi riferito al livello informativo/comunicativo che il contenuto offre e non invece all’aspetto emotivo che esso può suscitare.
In relation to the topic treated by the site, some content present may contain strong images or cruent scenes that could disturb the sensitivity in emotional people. For more information read the complete disclaimer.